Interleukin-1β, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk
نویسندگان
چکیده
منابع مشابه
Mitochondrial calcium handling and oxidative stress.
42. 43. 44. International Committee on Proteolysis (I.C.O.P.) Newsletter, August, p. 3 Taylor, A., Blondin, B., Davies, K. J. A. and Murakami, K. (1987) Abstr. 4th Int. Cong. Oxygen Radicals, W-20. Murakami, K., Jahngen, J. H., Lin, S. W., Davies, K. J. A. and Taylor, A. (1 989) Free Radical Biol. Med. 8 ,2 17-222 Levine, R. I,., Oliver, C. N., Fulks, R. M. and Stadtman, E. R. (1981) Proc. Natl...
متن کاملAbnormal Calcium Handling in Muscular Dystrophy
Duchenne muscular dystrophy, primarily caused by a deficiency in the membrane cytoskeletal protein dystrophin, is the most frequent neuromuscular disorder in humans and is characterized by progressive muscle weakness and wasting. This review outlines pathophysiological mechanisms of abnormal calcium handling by the sarcolemma, sarcoplasmic reticulum and mitochondria that may contribute to muscl...
متن کاملActivated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis
Platelets release preformed mediators and generate eicosanoids that regulate acute hemostasis and inflammation, but these anucleate cytoplasts are not thought to synthesize proteins or cytokines, or to influence inflammatory responses over time. Interrogation of an arrayed cDNA library demonstrated that quiescent platelets contain many messenger RNAs, one of which codes for interleukin 1beta pr...
متن کاملThe Relationship between Inflammation, Oxidative Stress, and Metabolic Risk Factors in Type 2 Diabetic Patients
Abstract Objective: Globally, 3-5.2 percent of people suffer from diabetes which is one of the most serious metabolic disorders resulting in an increase in inflammatory biomarkers e.g. interleukin-6, tumor necrosis factor-alpha, and C-reactive protein. The aim of this study was to investigate the relationship between inflammation, oxidative stress and fasting blood glucose, lipid profile and a...
متن کاملMitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death.
BACKGROUND Previously, we showed that a mouse model (ACE8/8) of cardiac renin-angiotensin system activation has a high rate of spontaneous ventricular tachycardia and sudden cardiac death secondary to a reduction in connexin43 level. Angiotensin-II activation increases reactive oxygen species (ROS) production, and ACE8/8 mice show increased cardiac ROS. We sought to determine the source of ROS ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2021
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2020.11.002